Stellenbeschreibung
Scope of duties
· Work on the project “Global mapping of drug synergy landscapes using massively parallel Cas13d genetic interaction screening” within the German Cancer Aid-funded DEFEAT-PDAC consortium
· Investigate therapeutically relevant genetic dependencies and drug combinations in pancreatic ductal adenocarcinoma
· Perform and analyze high-throughput genetic interaction screens, particularly using Cas13d-based screening approaches
· Plan and conduct molecular and cell biological experiments to validate identified targets and drug synergies
· Investigate rational combination therapies, including combinations with RAS/KRAS inhibitors
· Work with pancreatic cancer cell lines and additional preclinical model systems
· Apply modern methods in cell biology, molecular biology, functional genomics and proteomics
· Quantitatively analyze, interpret and document experimental data
· Collaborate closely with research groups and technology platforms within the DEFEAT-PDAC network
· Present research findings at project meetings and scientific conferences and contribute to scientific publications
Our requirements
· A successfully completed university degree, preferably a Master’s degree or equivalent, in biology, biochemistry, molecular medicine, biotechnology or a related life-science discipline
· Strong interest in cancer biology, functional genomics, mechanisms of therapy resistance and translational cancer research
· Practical experience in cell and molecular biology, for example mammalian cell culture, transfection, RNA and protein analysis, immunoblotting or microscopy
· Previous experience with CRISPR-based technologies, genetic screens, proteomics, next-generation sequencing or bioinformatic data analysis is an advantage, but not mandatory
· Motivation to learn new experimental technologies and quantitative analysis methods
· A careful, structured and independent approach to scientific work
· Scientific curiosity, high motivation and enthusiasm for experimental research
· Strong communication and teamwork skills and an interest in working in an interdisciplinary and international research environment
· Very good written and spoken English
· German language skills are not required
Our offer
· An innovative and challenging PhD project within the DEFEAT-PDAC consortium, a national and internationally connected research network funded by German Cancer Aid
· An international and interdisciplinary research environment at the interface of cancer biology, functional genomics, proteomics and clinical translation
· State-of-the-art laboratories and access to advanced screening, proteomics, sequencing and data-analysis platforms
· Close collaboration with basic scientists, bioinformaticians and clinician scientists
· Structured scientific supervision and support for your professional and personal development
· Opportunities to participate in national and international conferences, workshops and training programmes
· A collaborative, supportive and inspiring working environment that encourages scientific independence and the development of your own ideas
· Employment according to the German public-sector collective agreement, including annual leave and additional benefits in accordance with the applicable regulations
· The position is initially funded for three years. Subject to a positive scientific re-evaluation, an extension for up to two additional years is possible
· The position is based at the LMU University Hospital, Campus Großhadern, in Munich
· The remuneration is based on the Collective Agreement for the Public Service of the Federal States (TV-Ärzte) including all allowances customary in the public service.
